The problem of false discoveries from a metrological point of view

Valid inference drawn from analysis of experimental results needs scientific grounds, whereas conclusions based on statistical significance tests or hypothesis testing may be problematic, especially when dealing with a multiplicity of tested hypotheses, as in experiments performed on bio-molecules....

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Bibliographic Details
Published in:Journal of physics. Conference series 2013-01, Vol.459 (1), p.12041-6
Main Author: D'Errico, Giampaolo E
Format: Article
Language:English
Subjects:
Acceptance
Acceptance criteria
Biomolecules
Criteria
Grounds
Hypotheses
Metrology
Physics
Rejection
Sound
Uncertainty
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Summary:Valid inference drawn from analysis of experimental results needs scientific grounds, whereas conclusions based on statistical significance tests or hypothesis testing may be problematic, especially when dealing with a multiplicity of tested hypotheses, as in experiments performed on bio-molecules. The problem of false discovery rate is focused in the present paper, aiming at eliciting application of sound criteria for rejection/acceptance of hypotheses and related methods of uncertainty characterisation.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/459/1/012041