Spheroid culture as a tool for creating 3D complex tissues

Highlights ► Spheroids improve the relevance of in vitro results. ► Spheroids serve as biological models of native tissues or engineered solutions. ► Spheroids are used as building blocks to form tissues. ► Spheroids in concert with other aggregated cell shapes allow for complex tissue architecture...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2013-02, Vol.31 (2), p.108-115
Main Authors: Fennema, Eelco, Rivron, Nicolas, Rouwkema, Jeroen, van Blitterswijk, Clemens, de Boer, Jan
Format: Article
Language:English
Subjects:
Aggregates
Animals
bioengineering
Biological and medical sciences
biomimicry
Biotechnology
Cell adhesion & migration
cell culture
Culture
Electrochemical machining
Extracellular Matrix
Fundamental and applied biological sciences. Psychology
high throughput screening
High-Throughput Screening Assays - methods
Humans
Internal Medicine
Methods
Microfluidics - methods
Platforms
Screening
Skin & tissue grafts
spheroid
Spheroids
Spheroids, Cellular
Studies
Three dimensional
Tissue Culture Techniques - methods
Tissue Engineering - methods
tissues
Vascular endothelial growth factor
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Summary:Highlights ► Spheroids improve the relevance of in vitro results. ► Spheroids serve as biological models of native tissues or engineered solutions. ► Spheroids are used as building blocks to form tissues. ► Spheroids in concert with other aggregated cell shapes allow for complex tissue architecture studies.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2012.12.003