Highly selective two-photon imaging of cysteine in cancerous cells and tissues

Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (76), p.14401-14404
Main Authors: Lee, Yun Hak, Ren, Wen Xiu, Han, Jiyou, Sunwoo, Kyoung, Lim, Ja-Yun, Kim, Jong-Hoon, Kim, Jong Seung
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell Line, Tumor
Cysteine
Cysteine - analysis
Fluorescence
Fluorescent Dyes - chemistry
Glutathione
Glutathione - analysis
Health
HeLa Cells
Hep G2 Cells
Homocysteine - analysis
Humans
Imaging
Mice
Microscopy, Fluorescence, Multiphoton - methods
Neoplasms - chemistry
Neoplasms - pathology
Optical Imaging - methods
Recognition
Spectrometry, Fluorescence
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Summary:Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc06038a