A Universal Law for Cell Uptake of One-Dimensional Nanomaterials

Understanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell...

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Bibliographic Details
Published in:Nano letters 2014-02, Vol.14 (2), p.1049-1055
Main Authors: Yi, Xin, Shi, Xinghua, Gao, Huajian
Format: Article
Language:English
Subjects:
Bacteria
Bending
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Materials science
Mechanical and acoustical properties of condensed matter
Mechanical properties of nanoscale materials
Membranes
Nanocrystalline materials
Nanomaterials
Nanoscale materials and structures: fabrication and characterization
Nanostructure
Nanotubes
Nanowires
Physics
Quantum wires
Switches
Uptakes
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Summary:Understanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell uptake of one-dimensional nanomaterials via receptor-mediated endocytosis is dominated by a single dimensionless parameter that scales with the membrane tension and radius of the nanomaterial and inversely with the membrane bending stiffness. It is shown that as cell membrane internalizes one-dimensional nanomaterials the uptake follows a near-perpendicular entry mode at small membrane tension but it switches to a near-parallel interaction mode at large membrane tension.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl404727m