Sol-Gel Synthesis and Characterization of SiO sub(2)-CaO-P sub(2)O sub(5)-SrO Bioactive Glass: In Vitro Study

Bioactive glass of the type CaO-SrO-P sub(2)O sub(5)-SiO sub(2) was obtained by the sol-gel processing method. Three samples containing 0 mol%, 5 mol% and 10 mol% of SrO were synthesized. The obtained bioactive glasses were characterized by the techniques such as, X-ray diffraction (XRD) and scannin...

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Bibliographic Details
Published in:Key engineering materials 2014-01, Vol.631, p.30-35
Main Authors: Solgi, S, Shahrezaee, M, Zamanian, A, Kashi, T S Jafarzadeh, Raz, Majid, Khoshroo, K, Tahriri, M
Format: Article
Language:English
Subjects:
Assaying
Biocompatibility
Glass
In vitro testing
Scanning electron microscopy
Short range order
Silicon dioxide
Sol gel process
Strontium
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Summary:Bioactive glass of the type CaO-SrO-P sub(2)O sub(5)-SiO sub(2) was obtained by the sol-gel processing method. Three samples containing 0 mol%, 5 mol% and 10 mol% of SrO were synthesized. The obtained bioactive glasses were characterized by the techniques such as, X-ray diffraction (XRD) and scanning electron microscope (SEM) and the effect of SrO/CaO substitution on in vitro biological properties of the synthesized glasses were evaluated and biocompatibility of the samples was measured using MTT assay. The results showed that incorporation of Sr in the obtained glass network did not result in any structural alteration of it due to the similar role of SrO compared with that of CaO. In vitro experiments with human osteosarcoma cell lines (MG-63) and MTT assay indicated that bioactive glass incorporating 5 mol% of Sr in the composition is non-toxic and revealed good biocompatibility.
ISSN:1013-9826
1662-9795
DOI:10.4028/www.scientific.net/KEM.631.30