Telomerase activity in mouse bone marrow and subpopulations of spleen colony-forming units

Telomerase activity is studied in mouse bone marrow and in splenic colonies produced by individual CFU characterized by different proliferative potential and time of colony formation (7-14 days). It is found that splenic CFU forming colonies on day 9 in culture exhibit maximum telomerase activity th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-03, Vol.127 (3), p.280-282
Main Authors: Todriya, T. V., Drize, N. I., Chertkov, I. L., Grimm, Ya, Tsander, A.
Format: Article
Language:English
Subjects:
Aging
Bone marrow
Colonies & territories
Telomerase
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Summary:Telomerase activity is studied in mouse bone marrow and in splenic colonies produced by individual CFU characterized by different proliferative potential and time of colony formation (7-14 days). It is found that splenic CFU forming colonies on day 9 in culture exhibit maximum telomerase activity that 5-fold surpassed telomerase activity in the original bone marrow.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433357