Cardiac complications and diabetes in thalassaemia major: a large historical multicentre study

Summary The relationship between diabetes mellitus (DM) and cardiac complications has never been systematically studied in thalassaemia major (TM). We evaluated a large retrospective historical cohort of TM to determine whether DM is associated with a higher risk of heart complications. We compared...

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Published in:British journal of haematology 2013-11, Vol.163 (4), p.520-527
Main Authors: Pepe, Alessia, Meloni, Antonella, Rossi, Giuseppe, Caruso, Vincenzo, Cuccia, Liana, Spasiano, Anna, Gerardi, Calogera, Zuccarelli, Angelo, D'Ascola, Domenico G., Grimaldi, Salvatore, Santodirocco, Michele, Campisi, Saveria, Lai, Maria E., Piraino, Basilia, Chiodi, Elisabetta, Ascioti, Claudio, Gulino, Letizia, Positano, Vincenzo, Lombardi, Massimo, Gamberini, Maria R.
Format: Article
Language:English
Subjects:
Adult
Anemias. Hemoglobinopathies
beta-Thalassemia - complications
beta-Thalassemia - diagnosis
beta-Thalassemia - metabolism
beta-Thalassemia - pathology
Biological and medical sciences
cardiac complications
cardiovascular magnetic resonance
Cohort Studies
diabetes mellitus
Diabetes Mellitus - metabolism
Diabetes Mellitus - pathology
Diabetic Cardiomyopathies - complications
Diabetic Cardiomyopathies - metabolism
Diseases of red blood cells
Female
Heart Diseases - complications
Heart Diseases - metabolism
Heart Diseases - pathology
Hematologic and hematopoietic diseases
Humans
Iron Overload - complications
Iron Overload - metabolism
Iron Overload - pathology
Male
Medical sciences
myocardial iron overload
Retrospective Studies
thalassaemia major
Tumors
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Summary:Summary The relationship between diabetes mellitus (DM) and cardiac complications has never been systematically studied in thalassaemia major (TM). We evaluated a large retrospective historical cohort of TM to determine whether DM is associated with a higher risk of heart complications. We compared 86 TM patients affected by DM with 709 TM patients without DM consecutively included in the Myocardial Iron Overload in Thalassaemia database where clinical/instrumental data are recorded from birth to the first cardiovascular magnetic resonance (CMR) exam. All of the cardiac events considered were developed after the DM diagnosis. In DM patients versus non‐DM patients we found a significantly higher frequency of cardiac complications (46·5% vs. 16·9%, P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12557