Corona-Charged Aerosol Detection: An Analytical Approach

An alternative to other universal detection methods like refractive index (RI), low wavelength or ultraviolet (UV), and evaporative light scattering detection (ELSD), chemiluminescent nitrogen detection is a relatively new method based upon aerosol charging and involves Corona-charged aerosol detect...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in analytical chemistry 2013-05, Vol.43 (2), p.64-78
Main Authors: Ligor, Magdalena, Studzińska, Sylwia, Horna, Aleš, Buszewski, Bogusław
Format: Article
Language:English
Subjects:
Aerosols
Analytical chemistry
applications
Charged aerosol detection
Charging
Corona
Corona-CAD
Detectors
Evaporative
Fluorescence
Light scattering
Peptides
Polymers
principles
Surfactants
Ultraviolet
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An alternative to other universal detection methods like refractive index (RI), low wavelength or ultraviolet (UV), and evaporative light scattering detection (ELSD), chemiluminescent nitrogen detection is a relatively new method based upon aerosol charging and involves Corona-charged aerosol detection (Corona-CAD). Some reports show that the sensitivity of this method is lower than that of fluorescence detection. Others confirm approximately five times higher sensitivity than conventional UV absorbance detection for selected analytes. This is the reason that Corona-CAD can be widely used for the determination of nonvolatile or semivolatile compounds, including: lipids, oligosaccharides, carbohydrates, proteins, steroids, surfactants, polymers, peptides, and others. The response of Corona-CAD is independent of chemical properties of the analyte. This article reviews applications of Corona-CAD and principles of the aerosol charging method as well as advantages and disadvantages of the method. The modern solution using an ultra detector, which brings charged aerosol detection to UHPLC, is also discussed.
ISSN:1040-8347
1547-6510
DOI:10.1080/10408347.2012.746134