Toward clinical differential phase contrast mammography: preliminary evaluations and image processing schemes

Phase contrast and scattering-based X-ray imaging are very promising tools for medical diagnostics because they are able to provide additional and complementary information to traditional absorption-based methods. In this work, we discuss the investigation of three native breast samples with a grati...

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Bibliographic Details
Published in:Journal of instrumentation 2013-05, Vol.8 (5), p.1-9
Main Authors: Stampanoni, M, Wang, Z, Thuering, T, David, C, Roessl, E, van Stevendaal, U, Koehlerv, T, Trippel, M, Singer, G, Kubik-Huch, R A, Hohl, M K, Hauser, N
Format: Article
Language:English
Subjects:
Diagnostic systems
Electron density
Fuses
Instrumentation
Interferometers
Phase contrast
Scattering
X-ray tubes
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Summary:Phase contrast and scattering-based X-ray imaging are very promising tools for medical diagnostics because they are able to provide additional and complementary information to traditional absorption-based methods. In this work, we discuss the investigation of three native breast samples with a grating interferometer equipped with a conventional X-ray tube, the full study being published in ref. [1]. We briefly introduce a method to fuse absorption, differential phase and scattering signals into a unique image with improved diagnostic contents. Our approach yields complementary and inaccessible information on the electron density distribution and the small-angle scattering power of the sample which could potentially answer clinically relevant, yet unresolved questions such as the capability to unequivocally discern between (pre-) malignant changes and post-operative scars or to distinguish cancer-invaded regions within healthy tissue.
ISSN:1748-0221
1748-0221
DOI:10.1088/1748-0221/8/05/C05009