Collision cross sections of high-mannose N-glycans in commonly observed adduct states - identification of gas-phase conformers unique to [M - H] super(-) ions

We report collision cross sections (CCS) of high-mannose N-glycans as [M + Na] super(+), [M + K] super(+), [M + H] super(+), [M + Cl] super(-), [M + H sub(2)PO sub(4)] super(-) and [M - H] super(-) ions, measured by drift tube (DT) ion mobility-mass spectrometry (IM-MS) in helium and nitrogen gases....

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Bibliographic Details
Published in:Analyst (London) 2015-09, Vol.140 (20), p.6799-6803
Main Authors: Struwe, W B, Benesch, J L, Harvey, D J, Pagel, K
Format: Article
Language:English
Subjects:
Adducts
Cross sections
Drift tubes
Helium
Spectrometry
Spectroscopy
Traveling waves
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Summary:We report collision cross sections (CCS) of high-mannose N-glycans as [M + Na] super(+), [M + K] super(+), [M + H] super(+), [M + Cl] super(-), [M + H sub(2)PO sub(4)] super(-) and [M - H] super(-) ions, measured by drift tube (DT) ion mobility-mass spectrometry (IM-MS) in helium and nitrogen gases. Further analysis using traveling wave (TW) IM-MS reveal the existence of distinct conformers exclusive to [M - H] super(-) ions.
ISSN:0003-2654
1364-5528
DOI:10.1039/c5an01092f