Induction and transfer of resistance to poisoning by Amorimia (Mascagnia) septentrionalis in goats

ABSTRACT Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non‐toxi...

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Bibliographic Details
Published in:Journal of applied toxicology 2014-02, Vol.34 (2), p.220-223
Main Authors: Duarte, Amélia L. L., Medeiros, Rosane M. T., Carvalho, Fabrício K. L., Lee, Stephen T., Cook, Daniel, Pfister, James A., Costa, Valéria M. M., Riet-Correa, Franklin
Format: Article
Language:English
Subjects:
Amorimia septentrionalis
Animals
Conditioning
Dose-Response Relationship, Drug
Failure
Fluoroacetates - isolation & purification
Fluoroacetates - toxicity
Goat Diseases - chemically induced
Goat Diseases - prevention & control
Goats
Heart
Heart failure
Malpighiaceae - toxicity
monofluoroacetate
monofluoroacetate degrading bacteria
Plant Poisoning - prevention & control
Plant Poisoning - veterinary
plant poisoning resistance
Poisoning
Ruminantia
Sodium
sudden death
Toxic
Toxicology
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Summary:ABSTRACT Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non‐toxic doses of A. septentrionalis. We also show that increased resistance to poisoning by A. septentrionalis can also be achieved by the transfaunation of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis, and perhaps other plant species containing MFA. Copyright © 2013 John Wiley & Sons, Ltd. Amorimiaseptentrionalis contains sodium monofluoroactetate and can cause acute heart failure in ruminants when ingested in toxic doses. In this study we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non‐toxic doses of A. septentrionalis. We also show that increased resistance to poisoning by A. septentrionalis can also be achieved by the transfaunation of ruminal content from goats previously conditioned to beresistant to naïve goats.
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.2860