Endocrine and testicular changes induced by olanzapine in adult Wistar rats

• Published in: Journal of applied toxicology 2013-01, Vol.33 (1), p.24-31
• Main Authors: de Siqueira Bringel, Simone, de Amorim Júnior, Adelmar Afonso, Amorim, Marleyne José Afonso Accioly Lins, Brito, Lorena Tavares, Morais, Rosana Nogueira, de Torres, Sandra Maria, Tenorio, Bruno Mendes, da Silva Junior, Valdemiro Amaro
• Format: Article
• Language: English
• Subjects: Animals; Antipsychotic Agents - toxicity; Apoptosis - drug effects; Benzodiazepines - toxicity; Body Weight - drug effects; Cell Count; Degeneration; Disturbances; Endocrine system; Epididymis - drug effects; Epididymis - pathology; Genital Diseases, Male - blood; Genital Diseases, Male - chemically induced; Genital Diseases, Male - pathology; Lesions; Lethargy - chemically induced; Male; Necrosis - chemically induced; Necrosis - pathology; olanzapine; Organ Size - drug effects; Prostate - drug effects; Prostate - pathology; Psychopharmacology; Psychotropic drugs; Rats; Rats, Wistar; Receptors; Reproductive system; Sertoli Cells - drug effects; Sertoli Cells - pathology; sperm production; Spermatocytes - drug effects; Spermatocytes - pathology; Spermatogenesis; Spermatogenesis - drug effects; testicular degeneration; testis; Testis - drug effects; Testis - pathology; Testosterone; Testosterone - blood; Toxicity; Weight reduction
• ISSN: 0260-437X; 1099-1263
• DOI: 10.1002/jat.1702

ABSTRACT Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen‐dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis. Copyright © 2011 John Wiley & Sons, Ltd. Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment and therapeutic support for schizophrenia. Olanzapine treatment induced a reduction in plasma testosterone levels, and testicular, epididymal and prostatic weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis.