Advances in shaking technologies

Shaking bioreactors are the most frequently used reactor system for screening and process optimization on a small scale. Their success can be attributed to their simple and functional design, which make shaking systems suitable for a large number of cost-efficient parallel experiments. Recently repo...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2012-06, Vol.30 (6), p.307-314
Main Authors: Klockner, Wolf, Buechs, Jochen
Format: Article
Language:English
Subjects:
Animals
Automation
Biological and medical sciences
Bioreactors
Biotechnology
Cell Culture Techniques
Cells, Cultured
containers
cost effectiveness
Culture
Fundamental and applied biological sciences. Psychology
Insecta
Internal Medicine
Mammals
Measurement techniques
Methods. Procedures. Technologies
Microorganisms
mixing
Monitoring
On-line systems
Oxygen
Oxygen transfer
Plant Cells
Process controls
Reactors
screening
Shaking
Small scale
Technological change
Various methods and equipments
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Summary:Shaking bioreactors are the most frequently used reactor system for screening and process optimization on a small scale. Their success can be attributed to their simple and functional design, which make shaking systems suitable for a large number of cost-efficient parallel experiments. Recently reported findings for oxygen transfer, power input, out-of-phase operation, hydromechanical stress and mixing in shaken bioreactors are summarized in this article. Novel monitoring techniques for the control of culture conditions in shake flasks and microtiter plates are described. The methods for characterizing culture conditions and the novel online measurement techniques that are summarized in this article can be utilized to tap the full potential of shaking reactor systems.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2012.03.001