Enhanced cytogenetic and antitumor effects by 9-nitrocamptothecin and antineoplastics

Enhanced sister chromatid exchange (SCE) frequency by either melphalan (Mel) or epirubicin (Epir) was observed when human lymphocytes were exposed in vitro to 9‐nitro‐20(S)‐camptothecin (9NC). A correlation was observed between the magnitude of the SCE response and the depression of the cell prolife...

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Bibliographic Details
Published in:Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 2000, Vol.20 (3), p.141-146
Main Authors: Karaberis, E., Mourelatos, D.
Format: Article
Language:English
Subjects:
9-nitro-20(S)-camptothecin
9-nitrocamtothecin
Animals
antineoplastic activity
Antineoplastic agents
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Camptothecin - pharmacology
Camptothecin - therapeutic use
Cell Division - drug effects
cell kinetics
Chemotherapy
Drug Screening Assays, Antitumor
epirubicin
Epirubicin - administration & dosage
Epirubicin - pharmacology
Epirubicin - therapeutic use
Humans
Leukemia P388 - drug therapy
Lymphocytes - drug effects
Lymphocytes - ultrastructure
Medical sciences
melphalan
Melphalan - administration & dosage
Melphalan - pharmacology
Melphalan - therapeutic use
Mice
Pharmacology. Drug treatments
SCE
Sister Chromatid Exchange - drug effects
Citations: Items that this one cites
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Summary:Enhanced sister chromatid exchange (SCE) frequency by either melphalan (Mel) or epirubicin (Epir) was observed when human lymphocytes were exposed in vitro to 9‐nitro‐20(S)‐camptothecin (9NC). A correlation was observed between the magnitude of the SCE response and the depression of the cell proliferation index. The antitumor activity of Mel and of 9NC was tested on leukemia P‐388‐bearing mice. The two chemicals in combination enhance antitumor activity in a synergistic manner. Therefore, the in vivo antitumor effect of Mel in conjunction with 9NC appears to correlate well with the in vitro synergistic effect on SCE induction caused by the combined Mel plus 9NC treatment. Teratogenesis Carcinog. Mutagen. 20:141–146, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:0270-3211
1520-6866
DOI:10.1002/(SICI)1520-6866(2000)20:3<141::AID-TCM5>3.0.CO;2-D