Role of Homologous Recombination in the Alpha-Particle-Induced Bystander Effect for Sister Chromatid Exchanges and Chromosomal Aberrations

The bystander effect for sister chromatid exchanges (SCEs) and chromosomal aberrations was examined in hamster cell lines deficient in either DNA-PKcs (V3 cells, deficient in nonhomologous end joining, NHEJ) or RAD51C (irs3 cells, deficient in homologous recombination, HR). Cells synchronized in G s...

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Published in:Radiation research 2005-08, Vol.164 (2), p.141-147
Main Authors: Nagasawa, H, Peng, Y, Wilson, P F, Lio, Y, Chen, D J, Bedford, J S, Little, J B
Format: Article
Language:English
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Summary:The bystander effect for sister chromatid exchanges (SCEs) and chromosomal aberrations was examined in hamster cell lines deficient in either DNA-PKcs (V3 cells, deficient in nonhomologous end joining, NHEJ) or RAD51C (irs3 cells, deficient in homologous recombination, HR). Cells synchronized in G sub(0)/G sub(1) phase were irradiated with very low fluences of alpha particles such that
ISSN:0033-7587
DOI:10.1043/0033-7587(2005)164[0141:ROHRIT]2.0.CO;2