Determination of Ephedrine Alkaloids in Dietary Supplement Standard Reference Materials

A suite of five ephedra-containing dietary supplement Standard Reference Materials (SRMs) has been issued by the National Institute of Standards and Technology (NIST) with certified values for ephedrine alkaloids, synephrine, caffeine, and selected toxic trace elements. The materials represent a var...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2005-05, Vol.77 (10), p.3101-3112
Main Authors: Sander, Lane C, Sharpless, Katherine E, Satterfield, Mary B, Ihara, Toshihide, Phinney, Karen W, Yen, James H, Wise, Stephen A, Gay, Martha L, Lam, Joseph W, McCooeye, Margaret, Gardner, Graeme, Fraser, Catharine, Sturgeon, Ralph, Roman, Mark
Format: Article
Language:English
Subjects:
Alkaloids - analysis
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography, Liquid - methods
Chromatography, Liquid - standards
Comparative analysis
Dietary supplements
Dietary Supplements - analysis
Ephedrine - analysis
Exact sciences and technology
Food Analysis
Mass Spectrometry - methods
Mass Spectrometry - standards
Other chromatographic methods
Reference Standards
Reproducibility of Results
Sensitivity and Specificity
Spectrometric and optical methods
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Summary:A suite of five ephedra-containing dietary supplement Standard Reference Materials (SRMs) has been issued by the National Institute of Standards and Technology (NIST) with certified values for ephedrine alkaloids, synephrine, caffeine, and selected toxic trace elements. The materials represent a variety of natural, extracted, and processed sample matrixes that provide different analytical challenges. The constituents have been determined by multiple independent methods with measurements performed by NIST and by three collaborating laboratories. The methods utilized different sample extraction and cleanup steps in addition to different instrumental analytical techniques and approaches to quantification. In addition, food−matrix proximates were determined by National Food Processor Association laboratories for one of the ephedra-containing SRMs. The SRMs are primarily intended for method validation and for use as control materials to support the analysis of dietary supplements and related botanical materials.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac0484530