Insecticidal and Neuroblocking Activities toward American Cockroach (Periplaneta americana L.) of Imidacloprid Metabolites, 5-Hydroxy-, 4,5-Dihydroxy- and 4,5-Dehydroimidacloprid

• Published in: Journal of Pesticide Science 2004, Vol.29(4), pp.376-379
• Main Authors: Kagabu, Shinzo, Kato, Chie, Nishimura, Keiichiro
• Format: Article
• Language: English
• Subjects: American cockroach; Biological and medical sciences; Blattellidae; Control; Fundamental and applied biological sciences. Psychology; imidacloprid; metabolites of imidacloprid; neuroblocking potency; Periplaneta americana; Phytopathology. Animal pests. Plant and forest protection; Protozoa. Invertebrates; synergist
• ISSN: 1348-589X; 0385-1559; 1349-0923
• DOI: 10.1584/jpestics.29.376

The insecticidal and neuroblocking potencies of three imidacloprid metabolites were measured using American cockroaches. The minimum doses to cause paralysis 24 hr after injection of 4,5-dehydroimidacloprid (2) and 5-hydroxyimidacloprid (3) were about ten times larger than that for imidacloprid (1). Pretreatment with synergists, piperonyl butoxide and NIA16388, enhanced the activity: doses were 1.9, 1.7, and 0.071 nmol for compounds 2, 3 and 1, respectively. The concentrations of compounds 2 and 3 causing a neuroblock in the excised central nerve cord of the insects were respectively 49 and 150 μM, compared to 2.3 μM for 1. The potency of 4,5-dihydroxyimidacloprid (4) was far inferior in both measurements. Insecticidal effects of imidacloprid and possible metabolites were discussed. © Pesticide Science Society of Japan