Dearomatization of Indoles via Palladium-Catalyzed Allylic C–H Activation

The first Pd-catalyzed allylic dearomatization of substituted indoles triggered by C–H bond activation is reported. The presence of a catalytic amount of 2,5-DMBQ is proven to be a key factor for the high yield. This one-pot tandem allylic C–H activation/dearomatization sequence provides a straightf...

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Bibliographic Details
Published in:Organic letters 2016-01, Vol.18 (1), p.28-31
Main Authors: Zhang, Heng, Hu, Rong-Bin, Liu, Na, Li, Shi-Xia, Yang, Shang-Dong
Format: Article
Language:English
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Summary:The first Pd-catalyzed allylic dearomatization of substituted indoles triggered by C–H bond activation is reported. The presence of a catalytic amount of 2,5-DMBQ is proven to be a key factor for the high yield. This one-pot tandem allylic C–H activation/dearomatization sequence provides a straightforward access to 3,3-disubstituted indolines.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b03053