Alzheimer's disease: The amyloid hypothesis on trial

The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypot...

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Bibliographic Details
Published in:British journal of psychiatry 2016-01, Vol.208 (1), p.1-3
Main Authors: Harrison, Judith R., Owen, Michael J.
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Amyloid beta-Peptides - cerebrospinal fluid
Biomarkers - cerebrospinal fluid
Brain - diagnostic imaging
Clinical Trials as Topic
Editorials
Humans
Positron-Emission Tomography
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Summary:The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.115.167569