Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology : a minireview

A minireview is presented concerning the use of mercapturic acids as biological exposure index for electrophilic chemicals. Besides pure analytical aspects, this minireview considers possible issues in relation to (a) the added value of mercapturic acids as compared to other well validated biomarker...

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Bibliographic Details
Published in:International archives of occupational and environmental health 2005-06, Vol.78 (5), p.343-354
Main Authors: HAUFROID, V, LISON, D
Format: Article
Language:English
Subjects:
Acetylcysteine - urine
Belgium
Biological and medical sciences
Biomarkers
Biomonitoring
Chemicals
General aspects. Methods
Glutathione
Humans
Medical sciences
Occupational Exposure
Occupational health
Toxicogenetics
Toxicology
Urine
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Summary:A minireview is presented concerning the use of mercapturic acids as biological exposure index for electrophilic chemicals. Besides pure analytical aspects, this minireview considers possible issues in relation to (a) the added value of mercapturic acids as compared to other well validated biomarkers of exposure and (b) the high inter-individual variability in mercapturic acids excretion. Recent field and/or experimental studies confirm the usefulness of mercapturic acids as biological exposure index for electrophilic chemicals and suggest the interest of a toxicogenetic approach for a better interpretation of the results of biological monitoring.
ISSN:0340-0131
1432-1246
DOI:10.1007/s00420-005-0620-z