Loading…

The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer

Background The ability to identify men at genetically high‐risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa‐specific worry and risk perceptions) on men with a family history of PrCa,...

Full description

Saved in:
Bibliographic Details
Published in:Psycho-oncology (Chichester, England) England), 2015-11, Vol.24 (11), p.1492-1499
Main Authors: Bancroft, Elizabeth K., Castro, Elena, Bancroft, Gordon A., Ardern-Jones, Audrey, Moynihan, Clare, Page, Elizabeth, Taylor, Natalie, Eeles, Rosalind A., Rowley, Emma, Cox, Karen
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3
cites cdi_FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3
container_end_page 1499
container_issue 11
container_start_page 1492
container_title Psycho-oncology (Chichester, England)
container_volume 24
creator Bancroft, Elizabeth K.
Castro, Elena
Bancroft, Gordon A.
Ardern-Jones, Audrey
Moynihan, Clare
Page, Elizabeth
Taylor, Natalie
Eeles, Rosalind A.
Rowley, Emma
Cox, Karen
description Background The ability to identify men at genetically high‐risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa‐specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic‐risk profiling, within a research study. Methods A prospective exploratory approach was adopted, incorporating a sequential mixed‐method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic‐risk profiling. In‐depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach. Results Ninety‐five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: ‘feeling at risk’ and ‘living with risk’. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results. Conclusions Personalised genetic‐risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research. Copyright © 2015 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/pon.3814
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1755538839</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1755538839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3</originalsourceid><addsrcrecordid>eNqN0U1rFDEYB_BBFFur4CeQgBcvU_M6SY5StBVKK7LiMWQzz-ymnUnGZIY6374Zuu5BEDzlhV_-4eFfVW8JPicY049jDOdMEf6sOiVY65o0hDxf90LWmnJ9Ur3K-Q7jgnXzsjqhQklaDqfVsNkDGvPi9rGPO-9sj_wwWjeh2KE5tJB20Ycd2kGAybs6-XyPxhQ736_XPqABAnrw0x5Z1NnB9wva-zzFtKwJRebJToCcDQ7S6-pFZ_sMbw7rWfXjy-fNxVV9fXv59eLTde24xry2FBSmlFuKOwGtVEJtCQBIwihjTatVRyRrOeFbKSRlZZJGM6IKpLi8YWfVh6fc8v-vGfJkBp8d9L0NEOdsiBRCMKWY_g9KVdNIrUih7_-id3FOoQyyKs0xoSX1GOjK7DlBZ8bkB5sWQ7BZ2zKlLbO2Vei7Q-C8HaA9wj_1FFA_gQffw_LPIPPt9uYQePClAfh99Dbdm0YyKczPm0ujNlR-5xtuFHsEY8iq-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1729401255</pqid></control><display><type>article</type><title>The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer</title><source>Applied Social Sciences Index &amp; Abstracts (ASSIA)</source><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Bancroft, Elizabeth K. ; Castro, Elena ; Bancroft, Gordon A. ; Ardern-Jones, Audrey ; Moynihan, Clare ; Page, Elizabeth ; Taylor, Natalie ; Eeles, Rosalind A. ; Rowley, Emma ; Cox, Karen</creator><creatorcontrib>Bancroft, Elizabeth K. ; Castro, Elena ; Bancroft, Gordon A. ; Ardern-Jones, Audrey ; Moynihan, Clare ; Page, Elizabeth ; Taylor, Natalie ; Eeles, Rosalind A. ; Rowley, Emma ; Cox, Karen</creatorcontrib><description>Background The ability to identify men at genetically high‐risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa‐specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic‐risk profiling, within a research study. Methods A prospective exploratory approach was adopted, incorporating a sequential mixed‐method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic‐risk profiling. In‐depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach. Results Ninety‐five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: ‘feeling at risk’ and ‘living with risk’. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results. Conclusions Personalised genetic‐risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research. Copyright © 2015 John Wiley &amp; Sons, Ltd.</description><identifier>ISSN: 1057-9249</identifier><identifier>EISSN: 1099-1611</identifier><identifier>DOI: 10.1002/pon.3814</identifier><identifier>PMID: 25872100</identifier><identifier>CODEN: POJCEE</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Anxiety ; Anxiety - psychology ; At risk ; Early Detection of Cancer - psychology ; Follow-Up Studies ; Genetic family histories ; Genetic Predisposition to Disease - psychology ; Health Knowledge, Attitudes, Practice ; High risk ; Humans ; Male ; Medical screening ; Men ; Middle Aged ; Oncology ; Perceptions ; Profiles ; Prospective Studies ; Prostate ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - psychology ; Psychological aspects ; Psychological distress ; Qualitative Research ; Risk Assessment ; Risk communication ; Risk perception ; Surveys and Questionnaires</subject><ispartof>Psycho-oncology (Chichester, England), 2015-11, Vol.24 (11), p.1492-1499</ispartof><rights>Copyright © 2015 John Wiley &amp; Sons, Ltd.</rights><rights>Copyright Wiley Subscription Services, Inc. Nov 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3</citedby><cites>FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,30999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25872100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bancroft, Elizabeth K.</creatorcontrib><creatorcontrib>Castro, Elena</creatorcontrib><creatorcontrib>Bancroft, Gordon A.</creatorcontrib><creatorcontrib>Ardern-Jones, Audrey</creatorcontrib><creatorcontrib>Moynihan, Clare</creatorcontrib><creatorcontrib>Page, Elizabeth</creatorcontrib><creatorcontrib>Taylor, Natalie</creatorcontrib><creatorcontrib>Eeles, Rosalind A.</creatorcontrib><creatorcontrib>Rowley, Emma</creatorcontrib><creatorcontrib>Cox, Karen</creatorcontrib><title>The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer</title><title>Psycho-oncology (Chichester, England)</title><addtitle>Psycho-Oncology</addtitle><description>Background The ability to identify men at genetically high‐risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa‐specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic‐risk profiling, within a research study. Methods A prospective exploratory approach was adopted, incorporating a sequential mixed‐method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic‐risk profiling. In‐depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach. Results Ninety‐five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: ‘feeling at risk’ and ‘living with risk’. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results. Conclusions Personalised genetic‐risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research. Copyright © 2015 John Wiley &amp; Sons, Ltd.</description><subject>Adult</subject><subject>Aged</subject><subject>Anxiety</subject><subject>Anxiety - psychology</subject><subject>At risk</subject><subject>Early Detection of Cancer - psychology</subject><subject>Follow-Up Studies</subject><subject>Genetic family histories</subject><subject>Genetic Predisposition to Disease - psychology</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>High risk</subject><subject>Humans</subject><subject>Male</subject><subject>Medical screening</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Perceptions</subject><subject>Profiles</subject><subject>Prospective Studies</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - psychology</subject><subject>Psychological aspects</subject><subject>Psychological distress</subject><subject>Qualitative Research</subject><subject>Risk Assessment</subject><subject>Risk communication</subject><subject>Risk perception</subject><subject>Surveys and Questionnaires</subject><issn>1057-9249</issn><issn>1099-1611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqN0U1rFDEYB_BBFFur4CeQgBcvU_M6SY5StBVKK7LiMWQzz-ymnUnGZIY6374Zuu5BEDzlhV_-4eFfVW8JPicY049jDOdMEf6sOiVY65o0hDxf90LWmnJ9Ur3K-Q7jgnXzsjqhQklaDqfVsNkDGvPi9rGPO-9sj_wwWjeh2KE5tJB20Ycd2kGAybs6-XyPxhQ736_XPqABAnrw0x5Z1NnB9wva-zzFtKwJRebJToCcDQ7S6-pFZ_sMbw7rWfXjy-fNxVV9fXv59eLTde24xry2FBSmlFuKOwGtVEJtCQBIwihjTatVRyRrOeFbKSRlZZJGM6IKpLi8YWfVh6fc8v-vGfJkBp8d9L0NEOdsiBRCMKWY_g9KVdNIrUih7_-id3FOoQyyKs0xoSX1GOjK7DlBZ8bkB5sWQ7BZ2zKlLbO2Vei7Q-C8HaA9wj_1FFA_gQffw_LPIPPt9uYQePClAfh99Dbdm0YyKczPm0ujNlR-5xtuFHsEY8iq-w</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Bancroft, Elizabeth K.</creator><creator>Castro, Elena</creator><creator>Bancroft, Gordon A.</creator><creator>Ardern-Jones, Audrey</creator><creator>Moynihan, Clare</creator><creator>Page, Elizabeth</creator><creator>Taylor, Natalie</creator><creator>Eeles, Rosalind A.</creator><creator>Rowley, Emma</creator><creator>Cox, Karen</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer</title><author>Bancroft, Elizabeth K. ; Castro, Elena ; Bancroft, Gordon A. ; Ardern-Jones, Audrey ; Moynihan, Clare ; Page, Elizabeth ; Taylor, Natalie ; Eeles, Rosalind A. ; Rowley, Emma ; Cox, Karen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anxiety</topic><topic>Anxiety - psychology</topic><topic>At risk</topic><topic>Early Detection of Cancer - psychology</topic><topic>Follow-Up Studies</topic><topic>Genetic family histories</topic><topic>Genetic Predisposition to Disease - psychology</topic><topic>Health Knowledge, Attitudes, Practice</topic><topic>High risk</topic><topic>Humans</topic><topic>Male</topic><topic>Medical screening</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Perceptions</topic><topic>Profiles</topic><topic>Prospective Studies</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - psychology</topic><topic>Psychological aspects</topic><topic>Psychological distress</topic><topic>Qualitative Research</topic><topic>Risk Assessment</topic><topic>Risk communication</topic><topic>Risk perception</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bancroft, Elizabeth K.</creatorcontrib><creatorcontrib>Castro, Elena</creatorcontrib><creatorcontrib>Bancroft, Gordon A.</creatorcontrib><creatorcontrib>Ardern-Jones, Audrey</creatorcontrib><creatorcontrib>Moynihan, Clare</creatorcontrib><creatorcontrib>Page, Elizabeth</creatorcontrib><creatorcontrib>Taylor, Natalie</creatorcontrib><creatorcontrib>Eeles, Rosalind A.</creatorcontrib><creatorcontrib>Rowley, Emma</creatorcontrib><creatorcontrib>Cox, Karen</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index &amp; Abstracts (ASSIA)</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Psycho-oncology (Chichester, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bancroft, Elizabeth K.</au><au>Castro, Elena</au><au>Bancroft, Gordon A.</au><au>Ardern-Jones, Audrey</au><au>Moynihan, Clare</au><au>Page, Elizabeth</au><au>Taylor, Natalie</au><au>Eeles, Rosalind A.</au><au>Rowley, Emma</au><au>Cox, Karen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer</atitle><jtitle>Psycho-oncology (Chichester, England)</jtitle><addtitle>Psycho-Oncology</addtitle><date>2015-11</date><risdate>2015</risdate><volume>24</volume><issue>11</issue><spage>1492</spage><epage>1499</epage><pages>1492-1499</pages><issn>1057-9249</issn><eissn>1099-1611</eissn><coden>POJCEE</coden><abstract>Background The ability to identify men at genetically high‐risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa‐specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic‐risk profiling, within a research study. Methods A prospective exploratory approach was adopted, incorporating a sequential mixed‐method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic‐risk profiling. In‐depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach. Results Ninety‐five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: ‘feeling at risk’ and ‘living with risk’. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results. Conclusions Personalised genetic‐risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research. Copyright © 2015 John Wiley &amp; Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25872100</pmid><doi>10.1002/pon.3814</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1057-9249
ispartof Psycho-oncology (Chichester, England), 2015-11, Vol.24 (11), p.1492-1499
issn 1057-9249
1099-1611
language eng
recordid cdi_proquest_miscellaneous_1755538839
source Applied Social Sciences Index & Abstracts (ASSIA); Wiley-Blackwell Read & Publish Collection
subjects Adult
Aged
Anxiety
Anxiety - psychology
At risk
Early Detection of Cancer - psychology
Follow-Up Studies
Genetic family histories
Genetic Predisposition to Disease - psychology
Health Knowledge, Attitudes, Practice
High risk
Humans
Male
Medical screening
Men
Middle Aged
Oncology
Perceptions
Profiles
Prospective Studies
Prostate
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - psychology
Psychological aspects
Psychological distress
Qualitative Research
Risk Assessment
Risk communication
Risk perception
Surveys and Questionnaires
title The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T06%3A21%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20psychological%20impact%20of%20undergoing%20genetic-risk%20profiling%20in%20men%20with%20a%20family%20history%20of%20prostate%20cancer&rft.jtitle=Psycho-oncology%20(Chichester,%20England)&rft.au=Bancroft,%20Elizabeth%20K.&rft.date=2015-11&rft.volume=24&rft.issue=11&rft.spage=1492&rft.epage=1499&rft.pages=1492-1499&rft.issn=1057-9249&rft.eissn=1099-1611&rft.coden=POJCEE&rft_id=info:doi/10.1002/pon.3814&rft_dat=%3Cproquest_cross%3E1755538839%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4904-a2e80224a20f5ed7858b1eee7132336d98f173d414b75723100693187852020f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1729401255&rft_id=info:pmid/25872100&rfr_iscdi=true