Reduced occurrence of ventilator-associated pneumonia after cardiac surgery using preoperative 0.2% chlorhexidine oral rinse: results from a single-centre single-blinded randomized trial

Summary Since mechanical ventilation after cardiac surgery increases the risk of ventilator-associated pneumonia (VAP), we conducted a prospective randomized controlled trial to investigate the effect of preoperative 0.2% chlorhexidine on postoperative VAP. Ninety-four patients scheduled for heart s...

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Bibliographic Details
Published in:The Journal of hospital infection 2015-12, Vol.91 (4), p.362-366
Main Authors: Lin, Y.J, Xu, L, Huang, X.Z, Jiang, F, Li, S.L, Lin, F, Ye, Q.Y, Chen, M.L, Lin, J.L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Cardiac surgery
Chlorhexidine
Chlorhexidine - therapeutic use
Disinfectants - therapeutic use
Female
Humans
Incidence
Infectious Disease
Male
Middle Aged
Mouthwashes - therapeutic use
Pneumonia, Ventilator-Associated - epidemiology
Pneumonia, Ventilator-Associated - prevention & control
Prophylaxis
Prospective Studies
Single-Blind Method
Thoracic Surgery
Treatment Outcome
Ventilator-associated pneumonia
Young Adult
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Summary:Summary Since mechanical ventilation after cardiac surgery increases the risk of ventilator-associated pneumonia (VAP), we conducted a prospective randomized controlled trial to investigate the effect of preoperative 0.2% chlorhexidine on postoperative VAP. Ninety-four patients scheduled for heart surgery were randomized to a chlorhexidine group ( N  = 47) or control (saline) group ( N  = 47). On the day before surgery, patients gargled three times with 0.2% chlorhexidine or saline 30 min after each meal and 5 min after teeth brushing at bedtime. VAP occurred in 8.5% of the chlorhexidine group and in 23.4% of the controls. Preoperative chlorhexidine mouthwash reduced the incidence of postoperative VAP significantly.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2015.08.018