The Revolution of Hepatitis C Treatments: Review for Nurse Practitioners

Chronic hepatitis C virus infection has a widespread presence in the world’s population. Because of its potential for liver decompensation and secondary manifestations, hepatitis C virus has been the subject of many clinical trials over the past 20 years. This article will delineate the results of t...

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Bibliographic Details
Published in:Journal for nurse practitioners 2015-01, Vol.11 (1), p.116-123
Main Authors: Olson, Mary C., Gardenier, Donald, Jacobson, Ira M.
Format: Article
Language:English
Subjects:
cirrhosis
Diabetes
direct-acting antiviral
Drug dosages
FDA approval
Genomes
Genotype & phenotype
Hepatitis
Hepatitis C
Hepatitis C virus
HIV
Human immunodeficiency virus
Infections
Interferon
interferon free
Liver cancer
Liver cirrhosis
liver disease
Liver diseases
nurse practitioner
Proteins
Response rates
RNA polymerase
treatment experienced
treatment naive
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Summary:Chronic hepatitis C virus infection has a widespread presence in the world’s population. Because of its potential for liver decompensation and secondary manifestations, hepatitis C virus has been the subject of many clinical trials over the past 20 years. This article will delineate the results of these various studies. The interferon-free regimens with combinations of all oral antiviral combinations will provide improved tolerability and efficacy with sustained viral response rates greater than 90%. The outcomes and the commonly accepted methodologies for treatment, according to patient requirements, will be provided for the primary care nurse practitioner. •Revolution of Hepatitis C treatment from interferon based regimens to all oral interferon free regimens.•Review of pivotal clinical trial data for new Direct Acting Antiviral Regimens for HCV with SVR rates >90%.•Implications for the Primary Care Nurse Practitioner.
ISSN:1555-4155
1878-058X
DOI:10.1016/j.nurpra.2014.10.013