Protection against snake venom-induced neuronal injury by the new hypothalamic neurohormone

The action of PRP is characterized by the pronounced activation of the background activity (BA) of the brain spinal cord, and the degree of the activity depends on BA initial level. The typical peculiarity of Vipera raddei venom influence is the initial increase in frequency of BA with subsequent de...

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Bibliographic Details
Published in:Neurochemical research 2000-06, Vol.25 (6), p.791-800
Main Authors: GALOYAN, A. A, KIPRIYAN, T. K, SARKISSIAN, J. S, SARKISSIAN, E. J, GRIGORIAN, Y. Kh, ANDREASIAN, A. S, CHAVUSHYAN, E. A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamic Hormones - chemistry
Hypothalamic Hormones - pharmacology
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Male
Molecular Sequence Data
neurohormones
Neurons - drug effects
Neurons - pathology
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Peptides - chemistry
Peptides - pharmacology
Proline - chemistry
Proline-Rich Protein Domains
Rats
Snake Venoms - antagonists & inhibitors
Snake Venoms - toxicity
Spinal Cord - drug effects
Spinal Cord - pathology
Vertebrates: endocrinology
Vipera raddei
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Summary:The action of PRP is characterized by the pronounced activation of the background activity (BA) of the brain spinal cord, and the degree of the activity depends on BA initial level. The typical peculiarity of Vipera raddei venom influence is the initial increase in frequency of BA with subsequent depression. A preliminary injection of PRP has a protective effect at subsequent influence of venom. In animals with hemisection the PRP increases the decreased activity of neurons on injury side. Taking into consideration the protective peculiarities of PRP in the relationship to snake venom and the possibility of the latter to stabilize and prolong the action of drugs (in the case of PRP) combined with them, it is supposed that the mentioned use of the combination in clinical practice will be perspective. The data obtained testify the PRP to be a neuroprotector against many toxic compounds formed in organism (glutamate, ceramid, beta-amyloid neurotoxisity, etc.). Investigations in this aspect are still in the process.
ISSN:0364-3190
1573-6903
DOI:10.1023/A:1007561306432