Protection against snake venom-induced neuronal injury by the new hypothalamic neurohormone

• Published in: Neurochemical research 2000-06, Vol.25 (6), p.791-800
• Main Authors: GALOYAN, A. A, KIPRIYAN, T. K, SARKISSIAN, J. S, SARKISSIAN, E. J, GRIGORIAN, Y. Kh, ANDREASIAN, A. S, CHAVUSHYAN, E. A
• Format: Article
• Language: English
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Hormones and neuropeptides. Regulation; Hypothalamic Hormones - chemistry; Hypothalamic Hormones - pharmacology; Hypothalamus. Hypophysis. Epiphysis. Urophysis; Male; Molecular Sequence Data; neurohormones; Neurons - drug effects; Neurons - pathology; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Peptides - chemistry; Peptides - pharmacology; Proline - chemistry; Proline-Rich Protein Domains; Rats; Snake Venoms - antagonists & inhibitors; Snake Venoms - toxicity; Spinal Cord - drug effects; Spinal Cord - pathology; Vertebrates: endocrinology; Vipera raddei
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1023/A:1007561306432

The action of PRP is characterized by the pronounced activation of the background activity (BA) of the brain spinal cord, and the degree of the activity depends on BA initial level. The typical peculiarity of Vipera raddei venom influence is the initial increase in frequency of BA with subsequent depression. A preliminary injection of PRP has a protective effect at subsequent influence of venom. In animals with hemisection the PRP increases the decreased activity of neurons on injury side. Taking into consideration the protective peculiarities of PRP in the relationship to snake venom and the possibility of the latter to stabilize and prolong the action of drugs (in the case of PRP) combined with them, it is supposed that the mentioned use of the combination in clinical practice will be perspective. The data obtained testify the PRP to be a neuroprotector against many toxic compounds formed in organism (glutamate, ceramid, beta-amyloid neurotoxisity, etc.). Investigations in this aspect are still in the process.