The ATP levels in kidneys and blood are mainly decreased by acute ingestion of tullidora ( Karwinskia humboldtiana)

Our previous acute toxicity studies with Karwinskia humboldtiana (Kh) in rats showed renal hemodynamic changes with a marked increase in the fractional excretion of sodium and morphological damage. To analyse the effects of Kh or ‘tullidora’ on energetic metabolism, a single dose of an oral preparat...

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Bibliographic Details
Published in:Toxicon (Oxford) 2005-07, Vol.46 (1), p.99-103
Main Authors: Jaramillo-Juárez, F., Rodríguez-Vázquez, M.L., Muñoz-Martínez, J., Quezada-Tristán, T., Posadas del Río, F.A., Llamas-Viramontes, J., Ortíz, G. Gabriel, Feria-Velasco, Alfredo, Reyes, J.L.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - blood
Adenosine Triphosphate - metabolism
Animals
Biological and medical sciences
Haemoglobin-ATP
Karwinskia - toxicity
Karwinskia humboldtiana
Kidney - drug effects
Kidney - metabolism
Lethal Dose 50
Male
Medical sciences
Plant poisons toxicology
Plants, Toxic
Rats
Rats, Wistar
Renal ATP
Renal failure
Toxicology
Tullidora
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Summary:Our previous acute toxicity studies with Karwinskia humboldtiana (Kh) in rats showed renal hemodynamic changes with a marked increase in the fractional excretion of sodium and morphological damage. To analyse the effects of Kh or ‘tullidora’ on energetic metabolism, a single dose of an oral preparation from the seed fruits was given to Wistar rats (1.25 g/kg). In tullidora-treated rats there was 8% mortality. ATP concentrations in renal tissue decreased significantly (control: 53.85±3.34, tullidora 38.28±5.31 μmol/g fresh tissue, P
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2005.03.019