Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices

We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia ("ascend" at 5000 m). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This tr...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-10, Vol.138 (4), p.338-340
Main Authors: Semenov, D G, Miller, O L, Samoilov, M O
Format: Article
Language:English
Online Access:Get full text
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Summary:We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia ("ascend" at 5000 m). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This treatment abolished pathological calcium overload in brain slices induced in vitro by 10-min test anoxia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0035-6