XXII. Evaluation of drug efficacy by using animal models or in vitro systems

The efficacy of most therapeutic and prophylactic protocols against Pneumocystis carinii pneumonia used in human patients has been tested in animal models, especially in the corticosteroid-treated rat. The advantages and drawbacks of this model have been examined in brief in Chapter 1 of this sectio...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1998-09, Vol.22 (1), p.173-179
Main Authors: Brun Pascaud, Monique, Herreros, Esperanza, Aliouat, El Moukhtar, Dei-Cas, Eduardo
Format: Article
Language:English
Subjects:
Co-infection model
coinfection
Corticosteroid-treated rat
Metabolism
Nude rat
Pneumocystis carinii
Pneumocystis drug assay
Radiolabeled precursor
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Summary:The efficacy of most therapeutic and prophylactic protocols against Pneumocystis carinii pneumonia used in human patients has been tested in animal models, especially in the corticosteroid-treated rat. The advantages and drawbacks of this model have been examined in brief in Chapter 1 of this section. More recently, the nude rat, intratracheally inoculated with Pneumocystis, was used to test new anti-microbian molecules for their anti- Pneumocystis activity. In vitro systems, co-cultures of Pneumocystis with feeder cells as well as axenic cultures, were also used many times for drug screening. In this paper, the most used in vivo or in vitro drug screening systems are described. Moreover, as immunocompromised individuals, AIDS patients, especially, are often infected simultaneously by several infectious agents, a recent co-infection model is described.
ISSN:0928-8244
1574-695X
DOI:10.1016/S0928-8244(98)00076-5