Effect of Cassava on motor co-ordination and neurotransmitter level in the albino rat

The root of Cassava, a tropical plant, is consumed in the tropics and has been attributed as the cause for various tropical neuropathies. This study aims to discover the neurotoxic effects of chronic cassava consumption of Indian origin and the effect of malnutrition. The assessment is based on the...

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Bibliographic Details
Published in:Food and chemical toxicology 1999, Vol.37 (1), p.57-60
Main Authors: MATHANGI, D. C, MOHAN, V, NAMASIVAYAM, A
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Brain - physiopathology
Cassava
Dopamine - metabolism
Homovanillic Acid - metabolism
Indoles - metabolism
Levodopa - metabolism
Male
Manihot
Manihot - toxicity
Manihot esculenta
Medical sciences
Motor Skills - physiology
Neurotransmitter Agents - metabolism
Plant poisons toxicology
Protein-Energy Malnutrition - physiopathology
Rats
Rats, Wistar
Serotonin - metabolism
Solanum tuberosum
Toxicology
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Summary:The root of Cassava, a tropical plant, is consumed in the tropics and has been attributed as the cause for various tropical neuropathies. This study aims to discover the neurotoxic effects of chronic cassava consumption of Indian origin and the effect of malnutrition. The assessment is based on the motor co-ordination and brain neurotransmitters in rats. Cassava consumption reduced the motor co-ordination, but the changes in neurotransmitter levels due to cassava consumption (except for 5HT in corpus striatum) was identical with malnutrition-induced changes, indicating that the toxicity of chronic cassava consumption (of Indian origin) is mainly due to the associated protein calorie malnutrition (PCM).
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(98)00099-4