Experimental autoimmune encephalomyelitis induced in B6.C-H-2 super(bm12) mice by myelin oligodendrocyte glycoprotein: effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells

The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2 super(bm12) and H-2 super(b) mice. Despite only minor differences in TCRV beta expression and fine...

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Bibliographic Details
Published in:Journal of neuroimmunology 1999-04, Vol.96 (1), p.9-20
Main Authors: Mendel, I, Gur, H, Kerlero de Rosbo, N, Ben-Nun, A
Format: Article
Language:English
Subjects:
histocompatibility antigen H-2
myelin oligodendrocyte glycoprotein
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Summary:The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2 super(bm12) and H-2 super(b) mice. Despite only minor differences in TCRV beta expression and fine epitope specificity, H-2 super(bm12)/ and H-2 super(b)/prMOG35-55-specific T-cells failed to recognize A super(b) /prMOG35-55 and A super(bm12)/prMOG35-55, respectively. rhMOG-induced EAE was milder in H-2 super(bm12) mice, possibly as a result of co-dominant responses to prMOG35-55 and to the non-encephalitogenic pMOG94-116, rather than a single dominant response to prMOG35-55 in H-2 super(b) mice.
ISSN:0165-5728
DOI:10.1016/S0165-5728(99)00009-0