Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer's Disease Brain and Olfactory Epithelium

Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.

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Bibliographic Details
Published in:ChemMedChem 2013-06, Vol.8 (6), p.891-897
Main Authors: Gu, Jiamin, Anumala, Upendra Rao, Heyny-von Haußen, Roland, Hölzer, Jana, Goetschy-Meyer, Valérie, Mall, Gerhard, Hilger, Ingrid, Czech, Christian, Schmidt, Boris
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Brain - metabolism
Brain - pathology
Carbocyanines - chemical synthesis
Carbocyanines - chemistry
Carbocyanines - pharmacology
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Hep G2 Cells
Humans
imaging agents
Male
Molecular Structure
neurodegenerative diseases
neurofibrillary tangles
olfactory epithelium
Olfactory Mucosa - chemistry
Olfactory Mucosa - metabolism
Olfactory Mucosa - pathology
Structure-Activity Relationship
tau Proteins - analysis
Zebrafish - embryology
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Description
Summary:Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201300090