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Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer's Disease Brain and Olfactory Epithelium
Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.
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| Published in: | ChemMedChem 2013-06, Vol.8 (6), p.891-897 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5380-bd4b1beac80ea2217e64daa9e5f7278c0e0bea84f6181ba938c1aeb9009a3e13 |
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| cites | cdi_FETCH-LOGICAL-c5380-bd4b1beac80ea2217e64daa9e5f7278c0e0bea84f6181ba938c1aeb9009a3e13 |
| container_end_page | 897 |
| container_issue | 6 |
| container_start_page | 891 |
| container_title | ChemMedChem |
| container_volume | 8 |
| creator | Gu, Jiamin Anumala, Upendra Rao Heyny-von Haußen, Roland Hölzer, Jana Goetschy-Meyer, Valérie Mall, Gerhard Hilger, Ingrid Czech, Christian Schmidt, Boris |
| description | Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques. |
| doi_str_mv | 10.1002/cmdc.201300090 |
| format | article |
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KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5380-bd4b1beac80ea2217e64daa9e5f7278c0e0bea84f6181ba938c1aeb9009a3e13</citedby><cites>FETCH-LOGICAL-c5380-bd4b1beac80ea2217e64daa9e5f7278c0e0bea84f6181ba938c1aeb9009a3e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23592568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gu, Jiamin</creatorcontrib><creatorcontrib>Anumala, Upendra Rao</creatorcontrib><creatorcontrib>Heyny-von Haußen, Roland</creatorcontrib><creatorcontrib>Hölzer, Jana</creatorcontrib><creatorcontrib>Goetschy-Meyer, Valérie</creatorcontrib><creatorcontrib>Mall, Gerhard</creatorcontrib><creatorcontrib>Hilger, Ingrid</creatorcontrib><creatorcontrib>Czech, Christian</creatorcontrib><creatorcontrib>Schmidt, Boris</creatorcontrib><title>Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer's Disease Brain and Olfactory Epithelium</title><title>ChemMedChem</title><addtitle>ChemMedChem</addtitle><description>Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. 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| fulltext | fulltext |
| identifier | ISSN: 1860-7179 |
| ispartof | ChemMedChem, 2013-06, Vol.8 (6), p.891-897 |
| issn | 1860-7179 1860-7187 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1758239709 |
| source | Wiley |
| subjects | Aged Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Brain - metabolism Brain - pathology Carbocyanines - chemical synthesis Carbocyanines - chemistry Carbocyanines - pharmacology Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology Hep G2 Cells Humans imaging agents Male Molecular Structure neurodegenerative diseases neurofibrillary tangles olfactory epithelium Olfactory Mucosa - chemistry Olfactory Mucosa - metabolism Olfactory Mucosa - pathology Structure-Activity Relationship tau Proteins - analysis Zebrafish - embryology |
| title | Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer's Disease Brain and Olfactory Epithelium |
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