Involvement of periostin–sclerostin–Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin

Periostin has an essential role in mechanotransduction in bone. Naringin, a natural flavonoid, has been evidenced for its osteoprotective role in osteoporosis, while its mechanism is far from clear. Here we show that down-regulation of periostin, and up-regulation of its downstream sclerostin and in...

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Published in:Biochemical and biophysical research communications 2015-12, Vol.468 (4), p.587-593
Main Authors: Lv, Jianwei, Sun, Xiaolei, Ma, Jianxiong, Ma, Xinlong, Xing, Guosheng, Wang, Ying, Sun, Lei, Wang, Jianbao, Li, Fengbo, Li, Yanjun
Format: Article
Language:English
Subjects:
Animals
Bone Morphogenetic Proteins - metabolism
Cell Adhesion Molecules - metabolism
Disuse osteoporosis
Dose-Response Relationship, Drug
Flavanones - administration & dosage
Genetic Markers
Male
Naringin
Neurosurgical Procedures - adverse effects
Osteoporosis - drug therapy
Osteoporosis - etiology
Osteoporosis - metabolism
Periostin
Rats
Rats, Sprague-Dawley
Sciatic Nerve - surgery
Sclerostin
Treatment Outcome
Wnt Signaling Pathway - drug effects
β-catenin
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Summary:Periostin has an essential role in mechanotransduction in bone. Naringin, a natural flavonoid, has been evidenced for its osteoprotective role in osteoporosis, while its mechanism is far from clear. Here we show that down-regulation of periostin, and up-regulation of its downstream sclerostin and inactivation of Wnt/β-catenin signaling were implicated in neurectomy-induced bone loss. Naringin could up-regulate periostin and prevent neurectomy-induced deterioration of BMD, trabecular microstructure and bone mechanical characteristics. In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/β-catenin signaling pathways. •Naringin prevents bone loss induced by disuse osteoporosis via sciatic neurectomy.•Naringin exerts its osteoprotective role via stimulating Wnt/β-catenin signaling.•Naringin stimulates Wnt/β-catenin signal via decreasing sclerostin expression.•Naringin inhibits sclerostin expression via up-regulation of periostin.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2015.10.152