Fetal alcohol exposure attenuates interleukin-1β-induced fever: neuroimmune mechanisms

Central mechanisms for the attenuating effects of fetal alcohol exposure (FAE) on interleukin-1β (IL-1)-induced fever were studied in adult male offspring of dams fed a liquid diet supplemented with ethanol (E), in pair-fed (P) control and in normal (N) offspring. Hypothalamic levels of IL-1 were si...

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Bibliographic Details
Published in:Journal of neuroimmunology 1999-09, Vol.99 (1), p.44-52
Main Authors: Taylor, Anna N, Tio, Delia L, Yirmiya, Raz
Format: Article
Language:English
Subjects:
Brain
Fetal alcohol exposure
Fever
interleukin 1^b
interleukin 1b
Interleukin-1β
Prostaglandin-E 2
Rat
Sickness behavior
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Summary:Central mechanisms for the attenuating effects of fetal alcohol exposure (FAE) on interleukin-1β (IL-1)-induced fever were studied in adult male offspring of dams fed a liquid diet supplemented with ethanol (E), in pair-fed (P) control and in normal (N) offspring. Hypothalamic levels of IL-1 were significantly lower in E than in N rats at 2 h, but not at 4 and 6 h, after intraperitoneal administration of lipopolysaccharide. Fever induced by intracerebroventricular (icv) IL-1 was significantly lower in E than in N and P rats. In contrast, E rats showed a normal febrile response to icv prostaglandin-E 2. Thus, whereas FAE does not affect central thermoregulatory mechanisms, per se, FAE alters the kinetics of hypothalamic IL-1 production/appearance and decreases the responsiveness of central mechanisms which mediate the febrile response to IL-1.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(99)00102-2