Carbon Nanotube Nanoelectrode Array for Ultrasensitive DNA Detection

A nanoelectrode array based on vertically aligned multiwalled carbon nanotubes (MWNTs) embedded in SiO2 is used for ultrasensitive DNA detection. Characteristic electrochemical behaviors are observed for measuring bulk and surface-immobilized redox species. Sensitivity is dramatically improved by lo...

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Bibliographic Details
Published in:Nano letters 2003-05, Vol.3 (5), p.597-602
Main Authors: Li, Jun, Ng, Hou Tee, Cassell, Alan, Fan, Wendy, Chen, Hua, Ye, Qi, Koehne, Jessica, Han, Jie, Meyyappan, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diverse techniques
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
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Summary:A nanoelectrode array based on vertically aligned multiwalled carbon nanotubes (MWNTs) embedded in SiO2 is used for ultrasensitive DNA detection. Characteristic electrochemical behaviors are observed for measuring bulk and surface-immobilized redox species. Sensitivity is dramatically improved by lowering the nanotube density. Oligonucleotide probes are selectively functionalized to the open ends of nanotubes. The hybridization of subattomole DNA targets can be detected by combining such electrodes with Ru(bpy)3 2+ mediated guanine oxidation.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl0340677