Neurological manifestations of Hansen's disease and their management

Hansen's disease is almost eliminated from developed countries but in developing countries of Africa, Asia and Latin America leprosy is still considered to be a public health problem. Mycobacterium leprae have the affinity for peripheral nerves and neuropathy is a cardinal manifestation of the...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2005-10, Vol.107 (6), p.445-454
Main Authors: Agrawal, Amit, Pandit, Lekha, Dalal, Monica, Shetty, J.P.
Format: Article
Language:English
Subjects:
Bacterial Vaccines - adverse effects
Bacterial Vaccines - therapeutic use
Biological and medical sciences
Biopsy
Birth control
Developing countries
Disease
Drug Therapy, Combination
Hansen's disease
Humans
Immunization
LDCs
Lepra reactions
Leprostatic Agents - adverse effects
Leprostatic Agents - therapeutic use
Leprosy
Leprosy - diagnosis
Leprosy - drug therapy
Leprosy - pathology
Medical sciences
Mycobacterium leprae
Neuritic leprosy
Neurologic Examination - drug effects
Neurology
Neurosurgery
Patient education
Peripheral Nerves - drug effects
Peripheral Nerves - pathology
Peripheral Nervous System Diseases - diagnosis
Peripheral Nervous System Diseases - drug therapy
Peripheral Nervous System Diseases - pathology
Prognosis
Rehabilitation
Skin - innervation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:Hansen's disease is almost eliminated from developed countries but in developing countries of Africa, Asia and Latin America leprosy is still considered to be a public health problem. Mycobacterium leprae have the affinity for peripheral nerves and neuropathy is a cardinal manifestation of the disease. The nerve damage affects sensory, motor, and autonomic fibers resulting in the physical impairments and limitation of physical activities and social participation. Leprosy is a curable disease and treatment provided in the early stages will avert the disabilities. Approach to the neuritic leprosy depends on its clinical characteristics, nerve biopsy, and histological appearance of dermatological and neurological lesions. In this article we review the literature and discuss the pathology, clinical features, diagnosis and management of neurological manifestations of leprosy.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2005.03.007