Periodontitis and arterial stiffness: a systematic review and meta-analysis

Introduction and Aims Patients with periodontitis have a higher risk of cardiovascular diseases, although a causal relationship between these conditions remains unclear. Arterial stiffness is considered a marker of arteriosclerosis and a risk factor for cardiovascular diseases. A systematic review o...

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Bibliographic Details
Published in:Journal of clinical periodontology 2015-11, Vol.42 (11), p.977-987
Main Authors: Schmitt, Audrey, Carra, Maria Clotilde, Boutouyrie, Pierre, Bouchard, Philippe
Format: Article
Language:English
Subjects:
arterial stiffness
Cardiovascular Diseases
Dentistry
Humans
Periodontitis
Pulse Wave Analysis
pulse wave velocity
Risk Factors
systematic review
Vascular Stiffness
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Summary:Introduction and Aims Patients with periodontitis have a higher risk of cardiovascular diseases, although a causal relationship between these conditions remains unclear. Arterial stiffness is considered a marker of arteriosclerosis and a risk factor for cardiovascular diseases. A systematic review of the literature on clinical studies using pulse wave velocity (PWV) to assess arterial stiffness in patients with periodontitis was carried out to answer the following questions: (i) Do patients with periodontitis have impaired arterial stiffness compared to non‐periodontal diseased subjects? (ii) Is periodontal treatment effective as a means to improve arterial stiffness in patients with periodontitis? Literature Review Literature search was done on different databases up to September 2014. All clinical studies (excluding case reports) using PWV in patients with periodontitis were retrieved for a full‐text evaluation. A total of 10 studies were included. Patients with periodontitis have increased arterial stiffness compared to controls (PWV mean difference 0.85 m/s; 95% confidence interval: 0.53–1.16; p
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.12467