Novel Mn3[Co(CN)6]2@SiO2@Ag Core-Shell Nanocube: Enhanced Two-Photon Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Photothermal and Chemo-therapy

• Published in: Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-11, Vol.11 (44), p.5956-5967
• Main Authors: Wang, Dongdong, Guo, Zhen, Zhou, Jiajia, Chen, Jian, Zhao, Gaozheng, Chen, Ruhui, He, Mengni, Liu, Zhenbang, Wang, Haibao, Chen, Qianwang
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cell Death - drug effects; Cell Line, Tumor; chemotherapy; Cobalt - chemistry; Cyanides - chemistry; Doxorubicin; Drug Liberation; Female; Humans; Hyperthermia, Induced; imaging; Magnetic Resonance Imaging - methods; Manganese - chemistry; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Mice, Nude; MRI; Multimodal Imaging; nanocubes; Nanotechnology; Optical Imaging - methods; Photons; Phototherapy; photothermal therapy; Silicon Dioxide - chemistry; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; two-photon fluorescence; two‐photon fluorescence, imaging, nanocubes
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201502102

The versatile Mn3[Co(CN)6]2@SiO2@Ag core–shell NCs are prepared by a simple coprecipitation method. Ag nanoparticles with an average diameter of 12 nm deposited on the surface of Mn3[Co(CN)6]2@SiO2 through S–Ag bonding are fabricated in ethanol solution by reducing silver nitrate (AgNO3) with NaBH4. The NCs possess T1–T2 dual‐modal magnetic resonance imaging ability. The inner Prussian blue analogs (PBAs) Mn3[Co(CN)6]2 exhibit bright two‐photon fluorescence (TPF) imaging when excited at 730 nm. Moreover, the TPF imaging intensity displays 1.85‐fold enhancement after loading of Ag nanoparticles. Besides, the sample also has multicolor fluorescence imaging ability under 403, 488, and 543 nm single photon excitation. The as‐synthesized Mn3[Co(CN)6]2@SiO2@Ag NCs show a DOX loading capacity of 600 mg g−1 and exhibit an excellent ability of near‐infrared (NIR)‐responsive drug release and photothermal therapy (PTT) which is induced from the relative high absorbance in NIR region. The combined chemotherapy and PTT against cancer cells in vitro test shows high therapeutic efficiency. The multimodal treatment and imaging could lead to this material a potential multifunctional system for biomedical diagnosis and therapy. A versatile Mn3[Co(CN)6]2@SiO2@Ag core–shell nanocube is prepared by a simple coprecipitation method which possesses T1–T2 dual‐modal MRI ability and bright two‐photon fluorescence (TPF) imaging when excited at 730 nm. The TPF imaging intensity displays 1.85‐fold enhancement after loading of Ag nanoparticles.