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Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12-Month Randomized Controlled Trial
Objectives To assess whether resistance training (RT) slows the progression of white matter lesions (WMLs) in older women. Design Secondary analysis of a 52‐week randomized controlled trial of RT, the Brain Power Study. Setting Community center and research center. Participants Of 155 community‐dwel...
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Published in: | Journal of the American Geriatrics Society (JAGS) 2015-10, Vol.63 (10), p.2052-2060 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Objectives
To assess whether resistance training (RT) slows the progression of white matter lesions (WMLs) in older women.
Design
Secondary analysis of a 52‐week randomized controlled trial of RT, the Brain Power Study.
Setting
Community center and research center.
Participants
Of 155 community‐dwelling women aged 65 to 75 enrolled in the Brain Power Study, 54 who had evidence of WMLs on magnetic resonance imaging (MRI) at baseline were included in this secondary analysis.
Intervention
Participants were randomized to once‐weekly RT (1× RT), twice‐weekly RT (2× RT), or twice‐weekly balance and tone (BAT). Assessors were blinded to participant assignments.
Measurements
WML volume was measured using MRI at baseline and trial completion.
Results
At trial completion, the 2× RT group had significantly lower WML volume than the BAT group (P = .03). There was no significant difference between the BAT group and the 1× RT group at trial completion (P = .77). Among participants in the two RT groups, reduced WML progression over 12 months was significantly associated with maintenance of gait speed (correlation coefficient (r) = −0.31, P = .049) but not with executive functions (r = 0.30; P = .06).
Conclusion
Engaging in progressive RT may reduce WML progression. |
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ISSN: | 0002-8614 1532-5415 |
DOI: | 10.1111/jgs.13644 |