Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography

Highlights • We recorded neural activity using standard clinical ECoG grids, micro-ECoG grids, and intracortical micro-electrodes from human patients. • We found that non-penetrating micro-ECoG grid recorded neural activity at scales closer to penetrating intracortical micro-electrodes than clinical...

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Bibliographic Details
Published in:Clinical neurophysiology 2016-01, Vol.127 (1), p.591-601
Main Authors: Kellis, Spencer, Sorensen, Larry, Darvas, Felix, Sayres, Conor, O’Neill, Kevin, Brown, Richard B, House, Paul, Ojemann, Jeff, Greger, Bradley
Format: Article
Language:English
Subjects:
Brain computer interface (BCI)
Electrocorticography - instrumentation
Electrocorticography - standards
Electrodes, Implanted - standards
Human cerebral cortex
Humans
Male
Micro-electrocorticography grid
Microelectrodes - standards
Motor Cortex - physiology
Nerve Net - physiology
Neural engineering
Neural microtechnology
Neurology
Somatosensory Cortex - physiology
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Summary:Highlights • We recorded neural activity using standard clinical ECoG grids, micro-ECoG grids, and intracortical micro-electrodes from human patients. • We found that non-penetrating micro-ECoG grid recorded neural activity at scales closer to penetrating intracortical micro-electrodes than clinical ECoG grids. • These novel micro-electrode technologies are enabling examination of cortical activity at the scale of cortical columns and could lead to improved diagnostics and neural prosthetic applications.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2015.06.002