Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs)

Purpose To investigate the applicability of Bipolar Charge Analyzer (BOLAR), a new commercial instrument developed by Dekati Ltd., in simultaneously characterizing the bipolar electrostatic charge profile and measuring the size distribution of commercial metered dose inhalers (MDIs). Methods Intal F...

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Bibliographic Details
Published in:Pharmaceutical research 2016-02, Vol.33 (2), p.283-291
Main Authors: Leung, Sharon Shui Yee, Chiow, Adam Chong Ming, Ukkonen, Ari, Chan, Hak-Kim
Format: Article
Language:English
Subjects:
Aerosols - chemistry
Albuterol - chemistry
Anti-Asthmatic Agents - chemistry
Beclomethasone - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Bipolar disorder
Bronchodilator Agents - chemistry
Chemistry, Pharmaceutical - instrumentation
Cromolyn Sodium - chemistry
Equipment Design
Humans
Medical equipment
Medical Law
Metered Dose Inhalers
Nedocromil - chemistry
Particle Size
Pharmaceuticals
Pharmacology/Toxicology
Pharmacy
Research Paper
Static Electricity
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Summary:Purpose To investigate the applicability of Bipolar Charge Analyzer (BOLAR), a new commercial instrument developed by Dekati Ltd., in simultaneously characterizing the bipolar electrostatic charge profile and measuring the size distribution of commercial metered dose inhalers (MDIs). Methods Intal Forte ® (sodium cromoglycate), Tilade ® (nedocromil sodium), Ventolin ® (salbutamol sulphate), and QVAR ® (beclomethasone dipropionate) were used as model MDIs in this study. Three individual actuations of each MDI were introduced into the BOLAR at an air flow rate of 60 l/min. Charge and mass profiles for each actuation were determined. Results The BOLAR was found to have better performance in collecting valid charge data (≥80%) than valid mass data (≥50%). In all tested products, both positively and negatively charged particles were found in five defined size fractions between zero and 11.6 μm, with the charge magnitude decreased with increasing particle size. The net charge profiles obtained from the BOLAR qualitatively agreed with the results reported previously. In all suspension type MDIs, negligible masses were detected in the smallest size fraction (
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-015-1786-z