Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection

Purpose: To i) evaluate the effect of a restraint procedure (7 days, 2 h/day) on place learning after fimbria-fornix transection (FF), ii) investigate effects of early vs. late administration of restraint, and iii) establish effects of the restraint procedure on expression of brain derived neurotrop...

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Published in:Restorative neurology and neuroscience 2015-10, Vol.34 (1), p.1-17
Main Authors: Gram, Marie Gajhede, Wogensen, Elise, Wörtwein, Gitta, Mogensen, Jesper, Malá, Hana
Format: Article
Language:English
Subjects:
Animals
Body Weight
Brain Diseases - metabolism
Brain Diseases - therapy
Brain-Derived Neurotrophic Factor - metabolism
Cognition - physiology
Disease Models, Animal
Fornix, Brain - physiopathology
Fornix, Brain - surgery
Male
Maze Learning - physiology
Neurosurgical Procedures
Prefrontal Cortex - metabolism
Random Allocation
Rats, Wistar
Restraint, Physical - methods
Treatment Outcome
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Summary:Purpose: To i) evaluate the effect of a restraint procedure (7 days, 2 h/day) on place learning after fimbria-fornix transection (FF), ii) investigate effects of early vs. late administration of restraint, and iii) establish effects of the restraint procedure on expression of brain derived neurotrophic factor (BDNF) in prefrontal cortex and hippocampus. Methods: Fifty rats subjected to FF or sham surgery and divided into groups exposed to restraint immediately (early restraint) or 21 days (late restraint) after surgery were trained to acquire an allocentric place learning task. In parallel, 29 animals were subjected to FF or sham surgery and an identical restraint procedure in order to measure concentrations of BDNF and corticosterone. Results: The performance of the sham operated rats was positively affected by the late restraint. In FF-lesioned animals, the late restraint significantly improved task performance compared to the lesioned group with no restraint, while the early restraint was associated with a negative impact on task acquisition. Biochemical analysis after restraint procedure revealed a lesion-induced upregulation of BDNF in FF animals. Conclusions: The improved task performance of lesioned animals suggests a therapeutic effect of this manipulation, independent of BDNF. This effect is sensitive to the temporal administration of treatment.
ISSN:0922-6028
1878-3627
DOI:10.3233/RNN-140396