New developments in microextraction techniques in bioanalysis. A review

In recent years, the interest in new extraction methods with lower sample volume requirements, simpler equipment and handling, and lower reagent consumption, has led to the development of a series of microextraction methods based on extraction phases in the microliter order. Nowadays, many reference...

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Bibliographic Details
Published in:Analytica chimica acta 2016-01, Vol.905, p.8-23
Main Authors: Ocaña-González, Juan Antonio, Fernández-Torres, Rut, Bello-López, Miguel Ángel, Ramos-Payán, María
Format: Article
Language:English
Subjects:
Biological samples
Electromembrane microextraction
Lab-On-A-Chip Devices
Liquid phase microextraction
Liquid Phase Microextraction - methods
Membranes, Artificial
Microchip device
Nanoextraction
Solid phase microextraction
Solid Phase Microextraction - methods
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Summary:In recent years, the interest in new extraction methods with lower sample volume requirements, simpler equipment and handling, and lower reagent consumption, has led to the development of a series of microextraction methods based on extraction phases in the microliter order. Nowadays, many references can be found for several of these methods, which imply a wide range of applications referred to both the analyte and the sample nature. In this paper, recent developments in both well-established microextraction techniques (solid phase microextraction, hollow-fiber liquid phase microextraction, dispersive liquid–liquid microextraction, etc.) and recently appeared microextraction procedures (nanoextraction systems, microchip devices, etc.) for the clinical analysis of biological samples will be reviewed and discussed. [Display omitted] •Recent microextraction methods for bioanalysis are reviewed.•Fundamentals, recent developments and applications for each method are discussed.•Trends to miniaturization and on-chip extraction are highlighted.
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2015.10.041