Increased intracortical inhibition in elderly adults with anterior–posterior current flow: A TMS study

Highlights • We show no age-related difference in intracortical inhibition using a conventional (posterior–anterior) transcranial magnetic stimulation (TMS) coil orientation. • Using the more sensitive (anterior–posterior) TMS coil orientation, we show increased intracortical inhibition in older adu...

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Bibliographic Details
Published in:Clinical neurophysiology 2016-01, Vol.127 (1), p.635-640
Main Authors: Sale, Martin V, Lavender, Andrew P, Opie, George M, Nordstrom, Michael A, Semmler, John G
Format: Article
Language:English
Subjects:
Aged
Ageing
Aging - physiology
Electromyography - methods
Evoked Potentials, Motor - physiology
Female
Humans
Intracortical inhibition
Male
Motor cortex
Motor Cortex - physiology
Movement control
Neural Inhibition - physiology
Neurology
Transcranial magnetic stimulation
Transcranial Magnetic Stimulation - instrumentation
Transcranial Magnetic Stimulation - methods
Young Adult
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Summary:Highlights • We show no age-related difference in intracortical inhibition using a conventional (posterior–anterior) transcranial magnetic stimulation (TMS) coil orientation. • Using the more sensitive (anterior–posterior) TMS coil orientation, we show increased intracortical inhibition in older adults. • Reversing TMS current direction could be helpful to assess subtle differences in intracortical inhibition in clinical populations.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2015.04.062