Interactions between benign prostatic hyperplasia (BPH) and prostate cancer in large prostates: a retrospective data review

Purpose To study the interaction between benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Methods In this study, we performed a chart review of a cohort of 448 biopsy naive men. These men received a multi-core biopsy at our institution due to increased prostate-specific antigen (PSA) se...

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Bibliographic Details
Published in:International urology and nephrology 2016-01, Vol.48 (1), p.91-97
Main Authors: Al-Khalil, Shadi, Boothe, David, Durdin, Trey, Sunkara, Sowmya, Watkins, Phillip, Yang, Shengping, Haynes, Allan, de Riese, Werner
Format: Article
Language:English
Subjects:
Adult
Aged
Digital Rectal Examination
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Prostate-Specific Antigen - blood
Prostatic Hyperplasia - diagnostic imaging
Prostatic Hyperplasia - pathology
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - pathology
Retrospective Studies
Ultrasonography
Urology
Urology - Original Paper
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Summary:Purpose To study the interaction between benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Methods In this study, we performed a chart review of a cohort of 448 biopsy naive men. These men received a multi-core biopsy at our institution due to increased prostate-specific antigen (PSA) serum levels (>4 ng/ml) and/or suspicious findings on digital rectal examination in the years between 2008 and 2013. Utilizing PSA and transrectal ultrasound (TRUS) prostate volume, we obtained the PSA density (PSAD) for each individual. PSAD was calculated by dividing serum PSA concentration by TRUS prostate volume. Results Large prostates >65 g may secrete enough PSA to have a PSAD above the suggested cutoff of 0.15, yet 50 % patients have no histologic evidence of PCa, whereas prostates
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-015-1146-2