Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children

[...]the cells were washed, and flow cytometric analysis was performed immediately thereafter on a FACS scanner (Becton Dickinson Biosciences, Franklin Lakes, NJ). [...]Fig 2 shows the predicted concentration time course of rATG after 3 successive daily doses of 4 mg/kg administered over 12 hours.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-01, Vol.137 (1), p.306-309.e4
Main Authors: Bouazza, Naïm, PhD, Urien, Saik, MD, PhD, Neven, Bénédicte, MD, Moshous, Despina, MD, PhD, Nisoy, Jennifer, MSc, Gabrion, Aurélie, MSc, Cavazzana, Marina, MD, PhD, Blanche, Stéphane, MD, Tréluyer, Jean-Marc, MD, PhD, Touzot, Fabien, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Allergy and Immunology
Antilymphocyte Serum - pharmacology
Antilymphocyte Serum - therapeutic use
Child
Child, Preschool
Graft Rejection - prevention & control
Hematopoietic Stem Cell Transplantation
Humans
Immunosuppressive Agents - pharmacokinetics
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
Infant
Lymphocytes
Pediatrics
Population
Transplants & implants
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Description
Summary:[...]the cells were washed, and flow cytometric analysis was performed immediately thereafter on a FACS scanner (Becton Dickinson Biosciences, Franklin Lakes, NJ). [...]Fig 2 shows the predicted concentration time course of rATG after 3 successive daily doses of 4 mg/kg administered over 12 hours.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.06.003