The diagnostic efficacy of quantitative liver MR imaging with diffusion-weighted, SWI, and hepato-specific contrast-enhanced sequences in staging liver fibrosis—a multiparametric approach

Purpose To assess the diagnostic efficacy of multiparametric MRI using quantitative measurements of the apparent diffusion coefficient (ADC) of the liver parenchyma on diffusion-weighted imaging (DWI), signal intensity (SI) on susceptibility-weighted imaging (SWI), and gadoxetic acid-enhanced T1-wei...

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Bibliographic Details
Published in:European radiology 2016-02, Vol.26 (2), p.539-546
Main Authors: Feier, Diana, Balassy, Csilla, Bastati, Nina, Fragner, Romana, Wrba, Friedrich, Ba-Ssalamah, Ahmed
Format: Article
Language:English
Subjects:
Accuracy
Acids
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy
Contrast Media
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Female
Gadolinium DTPA
Hepatitis
Hospitals
Humans
Image Enhancement
Imaging
Internal Medicine
Interventional Radiology
Liver - pathology
Liver Cirrhosis - pathology
Liver diseases
Magnetic Resonance
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Pilot Projects
Radiology
Reproducibility of Results
Retrospective Studies
ROC Curve
Ultrasound
Young Adult
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Summary:Purpose To assess the diagnostic efficacy of multiparametric MRI using quantitative measurements of the apparent diffusion coefficient (ADC) of the liver parenchyma on diffusion-weighted imaging (DWI), signal intensity (SI) on susceptibility-weighted imaging (SWI), and gadoxetic acid-enhanced T1-weighted imaging during the hepatobiliary phase for the staging of liver fibrosis. Materials and Methods Seventy-seven patients underwent a 3T MRI examination, including DWI/SWI sequences and gadoxetic acid-enhanced T1-weighted MRI. Liver fibrosis according to liver biopsy was staged using the Metavir fibrosis score: F0 ( n  = 21, 27.3 %); F1 ( n  = 7, 9.1 %); F2 ( n  = 8, 10.4 %); F3 ( n  = 12, 15.6 %); and F4 ( n  = 29, 37.7 %). SI of the liver was defined using region-of-interest measurements to calculate the ADC values, the relative enhancement (RE) in the hepatobiliary phase, and the liver-to-muscle ratio (LMR) measurements for SWI. Results The values of RE, LMR, and ADC measurements were statistically significantly different among the five fibrosis stages ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-015-3830-0