Pentraxin-3 and nitric oxide as indicators of disease severity in alcoholic cirrhosis

• Published in: British journal of biomedical science 2015-01, Vol.72 (4), p.156-159
• Main Authors: Nandeesha, H., Rajappa, M., Manjusha, J., Ananthanarayanan, P.H., Harichandrakumar, T., Kadhiravan, K.T.
• Format: Article
• Language: English
• Subjects: Adult; Alcoholic; Aromatic rice; Biomarkers - blood; Biomedical research; Biopsy; C-Reactive Protein - analysis; Colorimetry; Cytokines; Enzyme-Linked Immunosorbent Assay; Gangrene; Heart attacks; Humans; Inflammation; Linear Models; Liver cirrhosis; Liver Cirrhosis, Alcoholic - blood; Liver Cirrhosis, Alcoholic - diagnosis; Liver diseases; Male; Middle Aged; Nitric oxide; Nitric Oxide - blood; Oxidative stress; Pathogenesis; Proteins; PTX3 protein; Regression analysis; Rodents; Sensitivity and Specificity; Serum Amyloid P-Component - analysis; Severity of Illness Index; Studies; Tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF
• ISSN: 0967-4845; 2474-0896
• DOI: 10.1080/09674845.2015.11665745

Recent studies have indicated that pentraxin-3 can be used as a marker to assess the severity of hepatic fibrosis in nonalcoholic steatohepatitis. The present study was designed to assess pentraxin-3, nitric oxide and tumour necrosis factor-α (TNFα) in alcoholic cirrhosis and their association with disease severity. We enrolled 47 alcoholic cirrhosis cases and 32 controls. Serum pentraxin-3, nitric oxide (NO) and TNFα levels were estimated in both groups. Serum pentraxin-3, NO and TNFα were significantly increased in alcoholic cirrhosis patients compared to controls. Pentraxin-3 had a significant positive correlation with TNFα (r=0.303, P=0.039), Child-Pugh score (r=0.394, P=0.006) and MELD score (r=0.291, P=0.047) in alcoholic cirrhosis cases. Also we found positive association between NO with Child-Pugh score (r=0.391, P=0.007) and MELD score (r=0.311, P=0.033) in these cases. Linear regression analysis shows significant association of pentraxin-3 and NO (β=0.375, r 2 =0.141, P=0.009). We conclude that elevated pentraxin-3 and NO levels are associated with severity of alcoholic cirrhosis.