Small Intestinal Submucosa Implantation for the Possible Treatment of Vocal Fold Scar, Sulcus, and Superficial Lamina Propria Atrophy

Objectives: Evaluate the histologic effects of grafting porcine-derived small intestinal submucosa (SIS) into the vocal fold superficial lamina propria (SLP) layer for the potential treatment of vocal fold scar, sulcus and superficial lamina propria atrophy. Methods: Small intestinal submucosa was i...

Full description

Saved in:
Bibliographic Details
Published in:Annals of otology, rhinology & laryngology rhinology & laryngology, 2016-02, Vol.125 (2), p.137-144
Main Authors: Pitman, Michael J., Cabin, Jonathan A., Iacob, Codrin E.
Format: Article
Language:English
Subjects:
Animals
Atrophy
Cicatrix
Disease Models, Animal
Dogs
Guided Tissue Regeneration - methods
Intestinal Mucosa - transplantation
Intestine, Small - transplantation
Mucous Membrane - pathology
Swine
Tissue Transplantation - methods
Transplants
Treatment Outcome
Vocal Cords - pathology
Vocal Cords - surgery
Voice Disorders - pathology
Voice Disorders - surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: Evaluate the histologic effects of grafting porcine-derived small intestinal submucosa (SIS) into the vocal fold superficial lamina propria (SLP) layer for the potential treatment of vocal fold scar, sulcus and superficial lamina propria atrophy. Methods: Small intestinal submucosa was implanted into the right vocal fold SLP of 6 mongrel dogs. The left vocal fold served as a sham surgical control. At 2, 4, and 6 weeks postoperative, bilateral vocal fold specimens were evaluated histologically. Results: At 2 and 4 weeks, respectively, SIS-implanted vocal folds demonstrated moderate and mild inflammation and acute and chronic inflammation. At 6 weeks, inflammation was minimal and chronic. The 6-week specimens showed copious amounts of newly generated hyaluronic acid (HA) within the graft. There was no reactive fibrosis at 6 weeks. Conclusions: In the canine model, SIS appears safe for SLP grafting. Inflammation is similar to that of sham surgery. Small intestinal submucosa results in newly generated HA without concomitant fibrosis. Small intestinal submucosa has potential to be used in treatment of disorders with SLP, including vocal fold scar, sulcus, and atrophy. Studies evaluating the effect of SIS implantation on vocal fold function, as well as the ultimate fate of the graft, are required.
ISSN:0003-4894
1943-572X
DOI:10.1177/0003489415601685