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Role of Glutathione System Redox Potential in Apoptosis Dysregulation in MCF-7 Breast Adenocarcinoma

MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The resu...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016, Vol.160 (3), p.364-367
Main Authors: Shakhristova, E. V., Stepovaya, E. A., Ryazantseva, N. V., Nosareva, O. L., Yakushina, V. D., Ivanov, V. V., Novitskii, V. V.
Format: Article
Language:English
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Summary:MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3172-1